Dr. Kim Greis

Additional information

Publication List

[39] K. Greis, L. F. Busse, L. R. Benzenberg, R. Wu, R. Zenobi*: How Native Are Peptides After Activation by Collisions or Photons? A Gas-Phase FRET Study, Helv. Chim. Acta 2025, accepted.

[38] Y. Xia, K. Greis, C. Xu, N. Kumar*, R. Zenobi*: Monitoring the On-Surface Boronic Acid Condensation Process at the Nanoscale Using Tip-Enhanced Raman Spectroscopy, ACS Nano 2025, 19, 6511.
DOI: https://doi.org/10.1021/acsnano.4c17728

[37] F. Dahlmann, C. E. Griesbach, A. Y. Torres-Boy, G. Von Helden, M. W. Peczuh, K. Pagel*, K. Greis*: Direct Experimental Characterization of a Sialyl Cation, Chem. Eur. J. 2025, 31, e202403724.
DOI: https://doi.org/10.1002/chem.202403724

[36] M. Safferthal,‡ K. Greis,‡ R. Chang,‡ C.-W. Chang, W. Hoffmann, G. Meijer, G. von Helden, K. Pagel*: The Impact of Side-Chain Fluorination on Proton-Bound Phenylalanine Simers: A Cryogenic Infrared Spectroscopy Study, Phys. Chem. Chem. Phys. 2024, 26, 28155.
DOI: https://doi.org/10.1039/D4CP03823A
‡ Authors contributed equally

[35] C.-W. Chang, K. Greis, G. R. D. Prabhu, D. Wehner, C. Kirschbaum, K. Ober, A. Y. Torres-Boy, S. Leichnitz, G. Meijer, G. von Helden, P. H. Seeberger, K. Pagel*: Mechanistic insight into benzylidene-directed glycosylation reactions using cryogenic infrared spectroscopy, Nat. Synth. 2024, 3, 1377.†
DOI: https://doi.org/10.1038/s44160-024-00619-0
† Featured in: https://doi.org/10.1038/s44160-024-00624-3

[34] C. Kirschbaum, K. Greis, A. Y. Torres-Boy, J. Riedel, S. Gewinner, W. Schöllkopf, G. Meijer, G. von Helden, K. Pagel*: Studying the Intrinsic Reactivity of Chromanes by Gas-Phase Infrared Spectroscopy, J. Am. Soc. Mass Spectrom. 2024, 35, 1950.
DOI: https://doi.org/10.1021/jasms.4c00216

[33] C. Kirschbaum*, K. Greis, S. Gewinner, W. Schöllkopf, G. Meijer, G. von Helden, K. Pagel, L. Urner*: Structure and Conformation Determine Gas-Phase Infrared Spectra of Detergents, ChemPlusChem 2024, 89, e202400340.†
DOI: https://doi.org/10.1002/cplu.202400340
† Editor’s Choice : Spotlights

[32] V. Kontodimas, M. Yaman, K. Greis, M. Lettow, K. Pagel, M. Marianski*: Reinvestigation of the Internal Glycan Rearrangement of Lewis a and Blood Group Type H1 Epitopes, Phys. Chem. Chem. Phys. 2024, 26, 14160.†
DOI: https://doi.org/10.1039/D3CP04491B
† 2024 HOT PCCP article

[31] T. Schleif, O. C. Moss, J. P. Messinger, A. G. Rullán Buxo, K. Greis, E. H. Perez, M. A. Johnson*: Hydrogen Tag Shifts as Vibrational Reporters for Positional Isomers of Formylphenides: Surprising Mobility of the Carbanion Center Upon Collisional Decarboxylation of the Parent Benzoates, J. Phys. Chem. Lett. 2024, 15, 1969.
DOI: https://doi.org/10.1021/acs.jpclett.3c03514

[30] K. Greis,* C. Kirschbaum, K. Ober, M. I. Taccone, A. Y. Torres-Boy, G. Meijer, K. Pagel, G. von Helden*: Infrared Spectroscopy of Fluorenyl Cations at Cryogenic Temperatures, J. Phys. Chem. Lett. 2023, 14, 11313.
DOI: https://doi.org/10.1021/acs.jpclett.3c02928

[29] M. Safferthal,‡ K. Greis,‡ R. Chang,‡ C. Kirschbaum, W. Hoffmann, G. Meijer, G. von Helden, K. Pagel*: Cryogenic Infrared Spectroscopy Reveals Remarkably Short NH⁺···F Hydrogen Bonds in Fluorinated Phenylalanines, Phys. Chem. Chem. Phys. 2023, 25, 23783.
DOI: https://doi.org/10.1039/D3CP03776B
‡ Authors contributed equally

[28] C. A. Lutomski, T. J. El-Baba, J. D. Hinkle, I. Liko, J. L. Bennett, N. V. Kalmankar, A. Dolan, C. Kirschbaum, K. Greis, L. Urner, P. Kapoor, H.-Y. Yen, K. Pagel, C. Mullen, J. E. P. Syma, C. V. Robinson*: Infrared Multiphoton Dissociation Enables Top-Down Characterization of Membrane Protein Complexes and G Protein-Coupled Receptors, Angew. Chem. Int. Ed. 2023, 62, e202305694.
DOI: https://doi.org/10.1002/anie.202305694

[27] S. J. Stropoli, K. Greis, T. Schleif, M. A. Johnson*: Characterization of Oxidation Products from HOCl Uptake by Microhydrated Methionine Anions Using Cryogenic Ion Vibrational Spectroscopy, J. Phys. Chem. A 2023, 127, 4269.
DOI: https://doi.org/10.1021/acs.jpca.3c00509

[26] K. Greis,‡ C. E. Griesbach,‡ C. Kirschbaum, G. Meijer, G. von Helden, K. Pagel*, M. W. Peczuh*: Characterization and Fate of a Septanosyl Ferrier Cation in the Gas and Solution Phases, J. Org. Chem. 2023, 88, 5543.
DOI: https://doi.org/10.1021/acs.joc.3c00079
‡ Authors contributed equally

[25] M. Lettow, K. Greis, E. Mucha, T. R. Lambeth, M. Yaman, V. Kontodimas, C. Manz, W. Hoffmann, G. Meijer, R. R. Julian, G. von Helden, M. Marianski*, K. Pagel*: Decoding the Fucose Migration Product during Mass-Spectrometric Analysis of Blood Group Epitopes, Angew. Chem. Int. Ed. 2023, 62, e202302883.
DOI: https://doi.org/10.1002/anie.202302883

[24] C. Kirschbaum, R. S. E. Young, K. Greis, J. P. Menzel, S. Gewinner, W. Schöllkopf, G. Meijer, G. von Helden, T. Causon, V. R. Narredulla, B. L. J. Poad, S. J. Blanksby*, K. Pagel*: Establishing Fatty Acid Double Bond Position and Configuration by Gas-Phase Infrared Spectroscopy. Chem. Sci. 2023, 14, 2518.†
DOI: https://doi.org/10.1039/D2SC06487A
† 2023 Chemical Science HOT Article Collection and 2023 ChemSci Pick of the Week Collection

[23] K. Greis,‡ S. Leichnitz,‡ C. Kirschbaum, C.-W. Chang, M.-H. Lin, G. Meijer, G. von Helden, P. H. Seeberger*, K. Pagel*: The Influence of the Electron Density in Acyl Protecting Groups on the Selectivity of Galactose Formation. J. Am. Chem. Soc. 2022, 144, 20258.†
DOI: https://doi.org/10.1021/jacs.2c05859
† Featured in: https://doi.org/10.1002/nadc.20234135542
‡ Authors contributed equally

[22] K. Greis*: Emerging scientists in analytical sciences: Kim Greis. Anal. Sci. Adv. 2022, 3, 258.
DOI: https://doi.org/10.1002/ansa.202200036

[21] E. H. Perez, T. Schleif, J. P. Messinger, A. G. Rullán Buxó, O. C. Moss, K. Greis, M. A. Johnson*: Structures and Chemical Rearrangements of Benzoate Derivatives Following Gas Phase Decarboxylation. J. Am. Soc. Mass Spectrom. 2022, 33, 1914.
DOI: https://doi.org/10.1021/jasms.2c00188

[20] T. Khuu, S. J. Stropoli, K. Greis, N. Yang, M. A. Johnson*: Microhydration of the metastable N-Protomer of 4-Aminobenzoic acid by condensation at 80 K: H/D exchange without conversion to the more stable O-Protomer. J. Chem. Phys. 2022, 157, 131102.
DOI: https://doi.org/10.1063/5.0119027

[19] K. Greis,‡ C. Kirschbaum,‡ M. I. Taccone, M. Götze, S. Gewinner, W. Schöllkopf, G. Meijer, G. von Helden, K. Pagel*: Studying the Key Intermediate of RNA Autohydrolysis by Cryogenic Gas-Phase Infrared Spectroscopy. Angew. Chem. Int. Ed. 2022, 61, e202115481.†
DOI: https://doi.org/10.1002/anie.202115481
Frontispiece DOI: https://doi.org/10.1002/anie.202281961
† Hot Paper
‡ Authors contributed equally

[18] K. Greis, C. Kirschbaum, G. Fittolani, E. Mucha, R. Chang, G. Meijer, G. von Helden,
M. Delbianco, P. H. Seeberger, K. Pagel*: Neighboring Group Participation of Benzoyl Protecting Groups in C3- and C6-Fluorinated Glucose. Eur. J. Org. Chem. 2022, e202200255.†
DOI: https://doi.org/10.1002/ejoc.202200255
† Top Downloaded article in 2022

[17] C. Kirschbaum,‡ K. Greis,‡ S. Gewinner, W. Schöllkopf, G. Meijer, G. von Helden, K. Pagel*: Cryogenic infrared spectroscopy provides mechanistic insight into the fragmentation of Ag(I)-adducted phospholipid isomers. Anal. Bioanal. Chem. 2022, 414, 5275.
DOI: https://doi.org/10.1007/s00216-022-03927-6
‡ Authors contributed equally

[16] K. Greis,‡ C. Kirschbaum,‡ G. von Helden, K. Pagel*: Gas-phase infrared spectroscopy of glycans and glycoconjugates. Curr. Opin. Struct. Biol. 2022, 72, 194.
DOI: https://doi.org/10.1016/j.sbi.2021.11.006
‡ Authors contributed equally

[15] M. Grabarics, M. Lettow, C. Kirschbaum, K. Greis, C. Manz, K. Pagel*: Mass Spectrometry-Based Techniques to Elucidate the Sugar Code. Chem. Rev. 2022, 122, 7840.
DOI: https://doi.org/10.1021/acs.chemrev.1c00380

[14] C. Kirschbaum, K. Greis, L. Polewski, S. Gewinner, W. Schöllkopf, G. Meijer, G. von Helden,
K. Pagel*: Unveiling Glycerolipid Fragmentation by Cryogenic Infrared Spectroscopy. J. Am. Chem. Soc. 2021, 143, 14827.
DOI: https://doi.org/10.1021/jacs.1c06944

[13] M. Lettow*, K. Greis, M. Grabarics, J. Horlebein, R. L. Miller, G. Meijer, G. von Helden, K. Pagel*: Chondroitin Sulfate Disaccharides in the Gas Phase: Differentiation and Conformational Constraints. J. Phys. Chem. A 2021, 125, 4373.
DOI: https://doi.org/10.1021/acs.jpca.1c02463

[12] C. Kirschbaum, K. Greis, M. Lettow, S. Gewinner, W. Schöllkopf, G. Meijer, G. von Helden, K. Pagel*: Non-covalent double bond sensors for gas-phase infrared spectroscopy of unsaturated fatty acids. Anal. Bioanal. Chem. 2021, 413, 3643.†
DOI: https://doi.org/10.1007/s00216-021-03334-3
† Paper in Forefront

[11] C. Kirschbaum, K. Greis, E. Mucha, L. Kain, S. Deng, A. Zappe, S. Gewinner, W. Schöllkopf, G. von Helden, G. Meijer, P. B. Savage, M. Marianski, L. Teyton, K. Pagel*: Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy. Nat. Commun. 2021, 12, 1201.†
DOI: https://doi.org/10.1038/s41467-021-21480-1
† Editors’ Highlights in “Organic chemistry and chemical biology”

[10] K. Greis, C. Kirschbaum, S. Leichnitz, S. Gewinner, W. Schöllkopf, G. von Helden, G. Meijer, P. H. Seeberger, K. Pagel*: Direct Experimental Characterization of the Ferrier Glycosyl Cation in the Gas Phase. Org. Lett. 2020, 22, 8916.†
DOI: https://doi.org/10.1021/acs.orglett.0c03301
† Featured in: https://doi.org/10.1002/nadc.20214105947

[9] D. A. Thomas, R. Chang, E. Mucha, M. Lettow, K. Greis, S. Gewinner, W. Schöllkopf, G. von Helden*: Probing the conformational landscape and thermochemistry of DNA dinucleotide anions via helium nanodroplet infrared action spectroscopy. Phys. Chem. Chem. Phys. 2020, 22, 18400.†
DOI: https://doi.org/10.1039/D0CP02482A
† 2020 HOT PCCP article

[8] M. Lettow, M. Grabarics, K. Greis, E. Mucha, D. A. Thomas, P. Chopra, G.-J. Boons, R. Karlsson, J. E. Turnbull, G. Meijer, R. L. Miller, G. von Helden, K. Pagel*: Cryogenic Infrared Spectroscopy Reveals Structural Modularity in the Vibrational Fingerprints of Heparan Sulfate Diastereomers. Anal. Chem. 2020, 92, 10228.
DOI: https://doi.org/10.1021/acs.analchem.0c02048

[7] K. Greis, E. Mucha, M. Lettow, D. A. Thomas, C. Kirschbaum, S. Moon, A. Pardo-Vargas, G. von Helden, G. Meijer, K. Gilmore, P. H. Seeberger, K. Pagel*: The Impact of Leaving Group Anomericity on the Structure of Glycosyl Cations of Protected Galactosides. ChemPhysChem 2020, 21, 1905.
DOI: https://doi.org/10.1002/cphc.202000473

[6] C. Kirschbaum, E. M. Saied, K. Greis, E. Mucha, S. Gewinner, W. Schöllkopf, G. Meijer, G. von Helden, B. L. J. Poad, S. J. Blanksby, C. Arenz*, K. Pagel*: Resolving Sphingolipid Isomers using Cryogenic Infrared Spectroscopy. Angew. Chem. Int. Ed. 2020, 59, 13638.†
DOI: https://doi.org/10.1002/anie.202002459
Cover Picture DOI: https://doi.org/10.1002/anie.202007701
† Hot Paper

[5] M. Marianski*, E. Mucha., K. Greis, S. Moon, A. Pardo, C. Kirschbaum, D. A. Thomas, G. Meijer, G. von Helden, K. Gilmore, P. H. Seeberger, K. Pagel*: Remote Participation during Glycosylation Reactions of Galactose Building Blocks: Direct Evidence from Cryogenic Vibrational Spectroscopy. Angew. Chem. Int. Ed. 2020, 59, 6166.
DOI: https://doi.org/10.1002/anie.201916245

[4] K. Greis, K. Bethke*, J. B. Stückrath, T. T. K. Ingber, S. Valiyaveettil, K. Rademann: One-Pot Synthesis of Xanthate Functionalized Cellulose for the Detection of Micromolar Copper(II) and Nickel(II) Ions. Clean – Soil, Air, Water 2019, 47, 1900179.†
DOI: https://doi.org/10.1002/clen.201900179
† Top Downloaded Paper in 2018-2019 and 2019-2020

[3] K. Greis, Y. Yang, A. J. Canty, R. A. J. O’Hair*: Gas-Phase Synthesis and Reactivity of Ligated Group 10 Ions in the Formal +1 Oxidation State. J. Am. Soc. Mass Spectrom. 2019, 30, 1867.
DOI: https://doi.org/10.1007/s13361-019-02231-5

[2] K. Greis, A. J. Canty, R. A. J. O’Hair*: Gas-Phase Reactions of the Group 10 Organometallic Cations, [(phen)M(CH₃)]⁺ with Acetone: Only Platinum Promotes a Catalytic Cycle via the Enolate [(phen)Pt(OC(CH₂)CH₃)]⁺. Z. Phys. Chem. 2019, 233, 845.
DOI: https://doi.org/10.1515/zpch-2018-1355

[1] K. Bethke, S. Palantöken, V. Andrei, M. Roß, V. S. Raghuwanshi, F. Kettemann, K. Greis, T. T. K. Ingber, J. B. Stückrath, S. Valiyaveettil, K. Rademann*: Functionalized Cellulose for Water Purification, Antimicrobial Applications, and Sensors. Adv. Funct. Mater. 2018, 28, 1800409.
DOI: https://doi.org/10.1002/adfm.201800409

 

Preprints

[1] S. Ponath, C. Joshi, A. T. Merrill, V. Schmidts, K. Greis, M. Lettow, M. Weber, S. Steinhauer, K. Pagel*, C. Thiele*, D. J. Tantillo*, M. J. Vetticatt*, M. Christmann*: On Stereocontrol in Organocatalytic α-Chlorinations of Aldehydes. ChemRxiv 2021.
DOI: https://doi.org/10.26434/chemrxiv.14229875.v1

 

Book Chapters

[1] M. Safferthal, L. Polewski, C.-W. Chang, K. Greis, K. Pagel: Cold-ion Spectroscopy of Carbohydrates. In Glycoprotein Analysis, New Developments in Mass Spectrometry No. 15, edited by W. B. Struwe, The Royal Society of Chemistry, 2024, 76.
DOI: https://doi.org/10.1039/9781839166433-00076

 

Oral Presentations

[18] Studying Unfolding of Peptides Using Gas-Phase FRET upon Activation by Photons and Collisions, 41^st SGMS Meeting, Beatenberg, Switzerland, October 2024.

[17] Direct Experimental Characterization of a Sialyl Cation, 13^th Conference on Isolated Biomolecules and Biomolecular Interactions, Timmendorfer Strand, Germany, April 2024.

[16] Structural Analysis of Glycosyl Cations and Other Reactive Intermediates Using Cryogenic Infrared Spectroscopy (Wolfgang-Paul-Preis Award Lecture), 55^th Annual Conference of the DGMS, Freising, Germany, March 2024.

[15] Structural Insight into Reactive Intermediates by Cryogenic Vibrational Spectroscopy and Computational Methods, 122^nd Annual Conference of the German Bunsen Society for Physical Chemistry, Berlin, Germany, June 2023.

[14] Structural Insight into Reactive Intermediates by Cryogenic Vibrational Spectroscopy and Computational Methods, 54^th Annual Conference of the DGMS, Dortmund, Germany, May 2023.

[13] Invited Seminar Presentation: Combining Cryogenic Vibrational Spectroscopy and Density Functional Theory to Determine Structures and Mechanisms in Chemistry, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland, November 2022.

[12] Isolating Elusive Cyclopentadienyl and Fluorenyl Cations in the Gas Phase, DGMS Young Scientists Fall Meeting, Hünfeld, Germany, September 2022.

[11] Determining Structural Motifs and Conformations of Glycosyl Cations by Cryogenic Gas-Phase Ion Infrared Spectroscopy, 24^th International Mass Spectrometry Conference (JMS Awardees session), Maastricht, Netherlands, September 2022.

[10] Invited Seminar Presentation: Cryogenic Vibrational Spectroscopy – A Tool for Studying Reactive Intermediates, University of Rhode Island, Kingston, USA, August 2022.

[9] Invited Seminar Presentation: Cryogenic Vibrational Spectroscopy – A Tool for Studying Reactive Intermediates, Northern Illinois University, DeKalb, USA, July 2022.

[8] Invited Seminar Presentation: Cryogenic Vibrational Spectroscopy – A Tool for Studying Reactive Intermediates, City University of New York, New York, USA, June 2022.

[7] Invited Seminar Presentation: Cryogenic Vibrational Spectroscopy – A Tool for Studying Reactive Intermediates, University of Connecticut, Storrs, USA, April 2022.

[6] Cryogenic Infrared Spectroscopy – A Tool for Understanding Mechanisms in Organic Chemistry, Chicago Mass Spec Day, online, July 2021.†
† Award for the best oral presentation

[5] Cryogenic Infrared Spectroscopy – A Tool for Understanding Mechanisms in Organic Chemistry, DGMS Young Scientists 1^st Digital Meeting, online, June 2021.

[4] Cryogenic Infrared Spectroscopy – A Tool for Understanding Mechanisms in Organic Chemistry, 120^th Annual Conference of the German Bunsen Society for Physical Chemistry, online, May 2021.

[3] Combining Mass Spectrometry-based Techniques with Quantum Chemical Modelling to Study Reactive Intermediates, Colloquium of the CRC 1349, online, April 2021.

[2] Direct Evidence for Remote Participation Revealed by Cryogenic Vibrational Spectroscopy, DGMS Young Scientists Fall Meeting, Hünfeld, Germany, September 2019.

[1] Catalytic Decomposition of Acetone and Acetic Acid Mediated by [(phen)Pt(O₂CCH₃)]⁺, Victorian Mass Spectrometry Symposium, Melbourne, Australia, December 2018.

 

Poster Presentations

[11] Using Gas-Phase FRET to Study the Structure of Diabetes-Related Polypeptides, SCS Fall Meeting, Fribourg, Switzerland, September 2024.

[10] Rearrangement of Certain Glycosyl Cations in the Gas Phase, GRS and GRC on Gaseous Ions: Structures, Energetics and Reactions, Ventura, USA, February 2023.

[9] Gas Phase Vibrational Analysis of Elusive Carbocations at Cryogenic Temperatures, Fachbeirat FHI, Berlin, Germany, November 2022.

[8] Studying the Key Intermediate of RNA Autohydrolysis by Cryogenic Gas-Phase Infrared Spectroscopy, Mass Spectrometry Summer School, Berlin, Germany, October 2022.

[7] Studying the Key Intermediate of RNA Autohydrolysis by Cryogenic Gas-Phase Infrared Spectroscopy, 24^th IMSC, Maastricht, Netherlands, September 2022.

[6] Gas-Phase Vibrational Analysis of Elusive Carbocations at Cryogenic Temperatures, Chicago MassSpec Day, Chicago, USA, July 2022.

[5] Cryogenic Vibrational Spectroscopy – A Tool for Understanding Reaction Mechanisms, 70^th ASMS Conference, Minneapolis, USA, June 2022.

[4] Neighboring and Remote Participation Studied by Cryogenic Vibrational Spectroscopy, Fachbeirat FHI, Berlin, Germany, November 2019.

[3] Remote Participation in Glycosylations Revealed by Cryogenic Vibrational Spectroscopy, Tag der Chemie, Berlin, Germany, July 2019.

[2] Catalytic Decomposition of Acetone and Acetic Acid Mediated by [(phen)Pt(O₂CCH₃)]⁺, RACI Victorian Inorganic Symposium, Melbourne, Australia, November 2018.

[1] Cellulose Based Chemicals for Heavy Metal Removal Studied by X-Ray-Fluorescence Spectroscopy (XRF), ICMAT, Singapore, June 2017.

 

Awards and Fellowships

• 2025 CAS Future Leaders Top 100 (Chemical Abstracts Service, March 2025)
• Kirkbright-Steers Award (Association of British Spectroscopists Trust, January 2025)
• 2024 CAS Future Leaders Top 100 (Chemical Abstracts Service, March 2024)
• Wolfgang-Paul-Promotionspreis (German Society for Mass Spectrometry, March 2025)
• Bursary Award (Association of British Spectroscopists Trust, January 2024)
• AFR Individual PhD Grant (Luxembourg National Research Fund, November 2019-October 2023)
• Selected as Emerging Scientist in Analytical Sciences by Analytical Science Advances (Wiley, October 2022)
• JMS Award (Journal of Mass Spectrometry, Wiley, September 2022)
• Participation at the 71st Lindau Nobel Laureate Meeting (June 2022)
• Fulbright Scholarship (associated with research stay at Yale University, February-July 2022)
• Masterpreis of the Division Analytical Chemistry (German Chemical Society, March 2020)
• Humboldt-Stipendium (Humboldt-Univeristät zu Berlin, April-September 2019)
• Scholarship of the German Academic Exchange Service (associated with research stay at The University of Melbourne, September-December 2018)
• Deutschlandstipendium (Humboldt-Universität zu Berlin, April 2016-March 2018)